Founders
Founder
Dr. Sharma is the Hillis Distinguished Chair of Medicine, director of Center for Precision Medicine, Vice Chair of Research and Chief of the Nephrology Division at the University of Texas Health San Antonio. He was previously the Director of the Institute for Metabolomic Medicine at University of California San Diego and had his fellowship and research training at the University of Pennsylvania. He has continuous NIH research funding for the past 30 years for his research which explores the mechanisms and treatment of acute and chronic kidney disease. His work has led to breakthroughs in understanding mitochondrial function in kidney disease and he is a global leader in metabolomic studies for novel biomarkers in kidney disease. Dr. Sharma has directed several multi-million dollar projects funded by National Institutes of Health and JDRF to identify novel paradigms and biomarkers for complications of diabetes and develop novel clinical trials in kidney disease. He served on numerous NIH study sections and was a standing member of the NIH Pathobiology of Kidney Disease study section. He plays a leading role in the NIH Kidney Precision Medicine program and directs the national hub for analysis of spatial metabolomic profiles of kidney tissues.
Publications
High-throughput metabolomics and diabetic kidney disease progression: evidence from the chronic renal insufficiency (CRIC) Study. Zhang J, Fuhrer T, Ye H, Kwan B, Montemayor D, Tumova J, Darshi M, Afshinnia F, Scialla JJ, Anderson A, Porter AC, Taliercio JJ, Rincon-Choles H, Rao P, Xie D, Feldman H, Sauer U, Sharma K, Natarajan L. American Journal of Nephrology, 2022 Feb 23:11, PMID 35196658
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Circulating free fatty acid and phospholipid signature predicts early rapid kidney function decline in patients with type 1 diabetes. Afshinnia F, Rajendiran TM, He C, Byun J, Montemayor D, Darshi M, Tumova J, Kim J, Limonte CP, Miller RG, Costacou T, Orchard TJ, Ahluwalia TS, Rossing P, Snell-Bergeon JK, de Boer IH, Natarajan L, Michailidis G, Sharma K, Pennathur S. Diabetes Care, 2021, September 44:2098-2106. PMID 34244329.
DESI-MSI and METASPACE indicates lipid abnormalities and altered mitochondrial membrane components in diabetic renal proximal tubules. Zhang G, Zhang J, DeHoog R, Pennathur S, Anderton CR, Venkatachalam MA, Alexandrov T, Eberlin LS, Sharma K. Metabolomics, 2020, Jan 10;16(1):11. doi: 10.1007/s11306-020-1637-8. PMID 31925564
The NASA Twins Study: A multi-dimensional analysis of a year-long human spaceflight. Garret-Bakelmen FE, Darshi M, Green SJ, Gur RC, Lin L, Macias BR, McKenna MJ, Meyden C, Mishra T, Nasrini J, Piening BD, Rizzardi LF, Sharma K, Siamwala JH, Taylor L,…, Mason CE, Mignot E, Rana BK, Smith SM, Snyder MP, Turek FW. Science, 2019, 2019 Apr 12;364(6436). PMID 30975860
The Warburg effect in diabetic kidney disease. Zhang G, Darshi M, Sharma K. Seminars in Nephrology. 2018, 38:111-120. PMID 29602394
Mass spectrometry imaging reveals elevated glomerular ATP/AMP in diabetes/obesity and identifies sphingomyelin as a possible mediator. Miyamoto, S, C-C, Hsu, Hamm, G., Darshi, M, Diamond-Stanic, M, Decleves, A-E, Slater, L, Pennathur, S, Stauber, J, Dorrestein, P, Sharma, K. EBioMedicine. 2016; 7:121-34. PMCID: PMC4909366.
Mitochondrial Hormesis and Diabetic Complications, Perspectives in Diabetes. Sharma, K. Diabetes, 2015 Mar;64(3):663-72. PMID:25713188
Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease. Börgeson E, Johnson AM, Lee YS, Till A, Syed GH, Ali-Shah ST, Guiry PJ, Dalli J, Colas RA, Serhan CN, Sharma K, Godson C. Cell Metabolism, 2015, 22:125-137. PMID 26052006.
AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function. Dugan LL, You YH, Ali SS, Diamond-Stanic M, Miyamoto S, DeCleves AE, Andreyev A, Quach T, Ly S, Shekhtman G, Nguyen W, Chepetan A, Le TP, Wang L, Xu M, Paik KP, Fogo A, Viollet B, Murphy A, Brosius F, Naviaux RK, Sharma K. J Clin Invest. 2013; 123:4888-99. PMCID: PMC3809777.
Adiponectin regulates albuminuria and podocyte function in mice. Sharma K, Ramachandrarao S, Qiu G, Usui HK, Zhu Y, Dunn SR, Ouedraogo R, Hough K, McCue P, Chan L, Falkner B, Goldstein BJ.J Clin Invest. 2008 May;118(5):1645-56. PMID: 18431508
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, Woollett LA, Csiszar A, Ikeno Y, Le Couteur D, Elliott PJ, Becker KG, Navas P, Ingram DK, Wolf NS, Ungvari Z, Sinclair DA, de Cabo R. Cell Metab. 2008 Aug;8(2):157-68. PMID: 18599363
Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice. Ziyadeh, F, Hoffman B, Han D, Iglesias-De La Cruz M, Hong S, Isono M , Chen S, McGowan T, Sharma K. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8015-20. PMID: 10859350